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 | What is SAM-e? |
|  SAM-e is a compound your body makes from an amino acid called methionine, which is commonly found in food. Cells in the body use SAM-e to make cartilage and repair cell damage. SAM-e, as a dietary supplement, is marketed for its ability to promote "joint health" and "emotional well being." The active ingredient in SAM-e is S-adenosylmethionine. SAM-e supplements seem to work as well as some over-the-counter products, including ibuprofen (brand name Motrin), and naproxen (Aleve), to decrease the pain of osteoarthritis. SAM-e also shows promise in the treatment of depression. In a few small studies, it was equally effective when compared to tricyclic antidepressants, like doxepin (Sinequan) or imipramine (Tofranil). But we need more studies to better understand these benefits and appropriate doses. SAM-e should be taken on an empty stomach in daily doses of 400 mg to 1600 mg with a maximum of 3600 mg per day. Since the potency of dietary supplements may vary, be sure to follow the instructions on the product packaging. Sources:Glorioso, S. "Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis," International Journal of Clinical Pharmacology Research 5 (1985).Salmaggi, P. "Double-blind, placebo-controlled study of S-adenosyl-L-methionine in depressed postmenopausal women," Psychotherapy and Psychosomatics 59 (1993).Grazi, S., M. Costa. SAMe (S-adenosylmethionine). Prima Publishing, 1999.The Natural Medicines Comprehensive Database. Pharmacists Letter Inc., 2001.Pepping, J. “Alternative Therapies: SAM-e: S-adenosylmethionine,” American Journal of Health-System Pharmacy V 57-2 (2000).Drug Facts and Comparisons. Facts & Comparisons, 2007.This answer prepared 3/8/2001. This information updated 1/18/2007. |
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