welcome: sign in|account|help
2 Sites 1 Bag
0 items $0.00checkout

Doctor's Best Double-Strength SAMe 400, Enteric Coated Tablets 60 ea

selected size: 60 ea
our price: $35.08$0.58 / ea
We're sorry but this item is temporarily out of stock.

Hidden Tab
Hidden Tab
Hidden Tab
Hidden Tab

Dietary Supplement

With 400 mg Active S-Adenosyl Methionine per Tablet

Science-Based Nutrition™

  • Helps Enhance Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade
  • Suitable for Vegetarians
  • Sealed in Blister Packs to Support Freshness & Convenience

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet.  Doctor's Best® utilizes only the highest quality Italian SAMe available on the market.  This helps ensure that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double-Strength SAMe is sealed in blister packs to support freshness and stability.

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system.  Methylation (donation of methyl groups) is an essential process for maintaining the proper function of a number of organ systems.  SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain.  SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe
The manufacturing process of SAMe yields 2 forms, the S,S and the R,S isomers.  The S,S isomer is the active form that helps mediate biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive.  The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe & Joint Function
SAMe may help enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue.  Clinical studies show an ability of SAMe promotes mobility, movement, and joint comfort.*

SAMe & Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote mood enhancement.  SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.*

SAMe & Liver Function
SAMe helps enhance liver synthesis of glutathione, an antioxidant.  Glutathione promotes detoxification and liver protection.  Studies show SAMe may help protect liver tissue from injury caused by a number of toxins.*

The SAMe found in Doctor's Best® SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat, and artificial flavoring.
Contains Nothing Other Than Listed Ingredients

(800) 777-2474

Made in Italy

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure or prevent any disease.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product.  Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe.  Do not use if pregnant or nursing.  May cause gastrointestinal discomfort in a small percentage of people.

©Doctor's Best, Inc