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Doctor's Best SAM-e 400mg 60tabs 60 ea

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Science-Based Nutrition™
Dietary Supplement with 400mg Active S-Adenosyl Methionine per Tablet

  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Pharmaceutical Grade

60 Enteric Coated Tablets Sealed in Blister Packs for Freshness & Convenience

Our Double-Strength SAMe 400 contains 400mg of active SAMe in each tablet.  Doctor's Best utilizes only the highest quality Italian SAMe available on the market.  This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Double-Strength SAMe is sealed in blister packs for freshness and stability.

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system.  Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems.  SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain.  SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers.  The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive.  The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function
SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue.  Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.*

SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood.  SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.*

SAMe and Liver Function
SAMe enhances liver synthesis of glutathione, an antioxidant.  Glutathione promotes detoxification and liver protection.  Studies show SAMe may protect liver tissue from injury caused by a number of toxins.*

The SAMe found in Doctor's Best SAMe 400mg (Double Strength), is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.

Suitable for Vegetarians

Contains nothing other than listed ingredients

800.777.2474 or drbvitamins.com

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure or prevent any disease.


Individual using antidepressant medications should consult with their prescribing physician prior to using this product.  Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe.  Do not use if pregnant or nursing.  May cause gastrointestinal discomfort in a small percentage of people.

Doctor's Best, Inc.

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