Learn more about usage, cautions, and possible side effects of Enbrel.
Chemical Name: ETANERCEPT (ee-TAN-er-sept)
Enbrel 4 25mg Kit is a type of protein called a tumor necrosis factor (TNF) inhibitor used to treat moderate to severe forms of ankylosing spondylitis (AS), juvenile arthritis, certain types of skin psoriasis, and rheumatoid and psoriatic arthritis. Enbrel 4 25mg Kit may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.
WARNING: SERIOUS AND SOMETIMES FATAL INFECTIONS (eg, bacterial, viral, or fungal infections; tuberculosis [TB]) have occurred in patients using Enbrel 4 25mg Kit. Most patients who developed these infections were taking medicines that weakened their immune systems (eg, methotrexate, corticosteroids). TB may be caused by a new infection or by reactivation of a previous infection. Your doctor will test you for TB and evaluate your risk for developing it. This will occur before, during, and after treatment with Enbrel 4 25mg Kit. If you have TB, you should begin to treat it before you begin treatment with Enbrel 4 25mg Kit. Tell your doctor if you have a history of persistent or recurring infections. CONTACT YOUR DOCTOR IMMEDIATELY if you develop signs of TB or any other type of infection (eg, persistent cough; muscle weakness; unexplained weight loss; fever, chills, or persistent sore throat; shortness of breath; unusual tiredness; warm, red, or painful skin; sores on your body; increased or painful urination). ENBREL 4 25mg KIT IS A TUMOR NECROSIS FACTOR (TNF)-BLOCKER. Lymphoma and other types of cancer have been reported in children and teenagers treated with TNF-blockers. This has been fatal in some cases. Talk with your doctor for more information. Some medicines or medical conditions may interact with Enbrel 4 25mg Kit. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE ENBREL 4 25mg KIT if you are taking cyclophosphamide, abatacept, or anakinra. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking amphetamines (eg, dextroamphetamine), decongestants (eg, pseudoephedrine), insulin or other diabetes medicines (eg, metformin), lithium, salicylates (eg, aspirin), sulfasalazine, or sulfonylureas (eg, glipizide). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including any kind of infection, including an infection that is in only one place in your body (such as an open sore), or an infection that is in your whole body (such as the flu); any numbness or tingling; a disease that affects your nervous system (eg, multiple sclerosis [MS], Guillain-Barre syndrome, seizures); congestive heart failure; a blood problem (eg, anemia); any lupus-like disease; rectal bleeding; shingles (herpes zoster); Wegener granulomatosis; a condition that may increase your risk of infection (eg, diabetes, HIV); allergies, including rubber or latex; pregnancy; or breast-feeding. Tell your doctor if you have a history of persistent or recurring infections, TB or a positive TB skin test, lymphoma or other cancers, liver problems (eg, hepatitis B), or liver problems caused by drinking alcohol (alcoholic hepatitis). Tell your doctor if you live in or have traveled to areas where fungal infections (eg, blastomycosis, coccidioidomycosis, histoplasmosis) are common, if you have been in close contact with someone who has had TB, or if you are scheduled to have major surgery or any kind of vaccination. Tell your doctor if you have a history of hepatitis B virus reactivation when taking Enbrel 4 25mg Kit or other TNF blockers. USE OF ENBREL 4 25mg KIT IS NOT RECOMMENDED if you have an infection that has spread throughout your entire body (sepsis), or if you have Wegener granulomatosis and are taking a medicine that may weaken the immune system (eg, corticosteroids, methotrexate). Contact your doctor or pharmacist if you have any questions or concerns about using Enbrel 4 25mg Kit.
Follow the directions for taking Enbrel 4 25mg Kit provided by your doctor. Enbrel 4 25mg Kit comes with an extra patient information sheet called a MEDICATION GUIDE approved by the U.S. Food and Drug Administration. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about Enbrel 4 25mg Kit. Enbrel 4 25mg Kit is given as an injection under the skin. A health care provider will provide detailed instructions for its appropriate use. Be sure you understand how to use Enbrel 4 25mg Kit. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. Wash your hands with soap and warm water before using Enbrel 4 25mg Kit. Use an alcohol swab to clean the gray stopper on the vial. DO NOT touch the stopper with your hands. Mix Enbrel 4 25mg Kit as instructed by your health care provider. DO NOT SHAKE Enbrel 4 25mg Kit. If all the powder in the vial is not dissolved or if there are particles present after 10 minutes, do not inject. Contact your health care provider. DO NOT USE ENBREL 4 25mg KIT if it is cloudy, discolored, contains particles, or if the vial is cracked or damaged in any way. Rotate the site for each injection. Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid areas with scars or stretch marks. If you have psoriasis, try not to inject directly into any raised, red, thick, or scaly skin patches. THE SYRINGE, NEEDLES, AND VIAL ADAPTER should never be reused. Never recap a needle. USE THE PROPER TECHNIQUE taught to you by your doctor. Inject deep under the skin, NOT into muscle. IT MAY TAKE SEVERAL WEEKS FOR ENBREL 4 25mg KIT TO WORK. Do not exceed the recommended dose, stop using Enbrel 4 25mg Kit, or use for longer than prescribed without checking with your doctor. STORE THE UNMIXED MEDICINE in its dose tray in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). THE MIXED MEDICINE may be stored in the refrigerator between 36 to 46 degrees F (2 and 8 degrees C) for up to 14 days. Do not freeze. Discard mixed solution after 14 days. KEEP THIS PRODUCT, as well as syringes and needles, out of the reach of children and away from pets. DO NOT MISS ANY DOSES of Enbrel 4 25mg Kit. IF YOU MISS A DOSE OF ENBREL 4 25mg KIT, contact your doctor immediately.
DO NOT USE ENBREL 4 25mg KIT if you have had an allergic reaction to it, to any ingredient in this product, or to rubber or latex. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS. ENBREL 4 25mg KIT MAY INTERFERE WITH CERTAIN LAB TESTS. Make sure laboratory personnel and your doctors know you use Enbrel 4 25mg Kit. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using Enbrel 4 25mg Kit. Enbrel 4 25mg Kit may cause dizziness. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to Enbrel 4 25mg Kit. Using Enbrel 4 25mg Kit alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. ENBREL 4 25mg KIT MAY REDUCE THE NUMBER OF BLOOD CELLS THAT ARE NEEDED FOR CLOTTING. To prevent bleeding, avoid situations where bruising or injury may occur. ENBREL 4 25mg KIT MAY LOWER YOUR RESISTANCE TO INFECTION. Avoid contact with people who have colds or infections. ENBREL 4 25mg KIT MAY INCREASE THE RISK OF DEVELOPING BLOOD CANCER (eg, leukemia, lymphoma) AND OTHER TYPES OF CANCER. This may be fatal in some cases. Tell your doctor if you have ever had cancer. Contact your doctor right away if you develop symptoms of leukemia or lymphoma such as unusual bruising, unusual lumps or swelling (eg, in your neck, armpit, or groin), night sweats, recurring fever, unusual tiredness or weakness, persistent unexplained itching, or unexplained weight loss. NEW OR WORSENING NERVOUS SYSTEM DISORDERS (eg, multiple sclerosis [MS], Guillain-Barre syndrome, seizures) have occurred in patients that take Enbrel 4 25mg Kit. Tell your doctor if you have a disease that affects your nervous system. BEFORE YOU BEGIN TAKING ANY NEW MEDICINES, either prescription or over-the-counter, check with your doctor or pharmacist. Discuss your vaccination history with your doctor to be sure that you are up to date on vaccinations. DO NOT RECEIVE A LIVE VACCINE while you are taking Enbrel 4 25mg Kit. Talk with your doctor before you receive any vaccine. IF YOU HAVE NOT HAD CHICKENPOX, SHINGLES, OR MEASLES, avoid contact with anyone who does. IF YOU DEVELOP any symptoms of TB (eg, dry cough that does not go away, fever, night sweats, weight loss), call your doctor. You will need to be examined for TB and have a skin test. CAUTION IS ADVISED WHEN USING ENBREL 4 25mg KIT IN CHILDREN; they may be at increased risk for developing certain types of cancer with Enbrel 4 25mg Kit, which may be fatal. CAUTION IS ADVISED WHEN USING ENBREL 4 25mg KIT IN THE ELDERLY because they may be more sensitive to the effects of the medicine. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using Enbrel 4 25mg Kit during pregnancy. IT IS UNKNOWN IF ENBREL 4 25mg KIT IS EXCRETED in breast milk. DO NOT BREAST-FEED while using Enbrel 4 25mg Kit. IF YOU HAVE DIABETES, Enbrel 4 25mg Kit may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
SIDE EFFECTS that may occur while taking Enbrel 4 25mg Kit include dizziness; headache; mild pain, redness, itching, bruising, or swelling around the injection site. If they continue or are bothersome, check with your doctor. SOME PATIENTS who use Enbrel 4 25mg Kit have developed new or worsening psoriasis. Tell your doctor right away if you notice any new or worsening skin problems (eg, red, flaky, or itchy skin patches). CONTACT YOUR DOCTOR IMMEDIATELY if you experience blood in the urine or stools; butterfly rash (rash on nose and cheeks); chest pain or discomfort; dark, tarry, or bloody stools; decreased mental alertness; fast heartbeat; fever, chills, or sore throat; general feeling of being unwell; increased or painful urination; mental/mood changes; new or worsening cough; numbness or tingling throughout your body; rapid breathing; rash on your face and arms that gets worse in the sun; seizures; shortness of breath; swelling of the arms or legs; swelling of the lymph nodes; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools); unusual bruising or bleeding; unusual lumps; unusual nausea, vomiting, stomach pain, or diarrhea; unusual tiredness or weakness; unusually pale skin; vision problems; or weakness in the arms or legs. AN ALLERGIC REACTION to Enbrel 4 25mg Kit is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions for Enbrel
If overdose is suspected, contact your local poison control center or emergency room immediately.
DO NOT SHARE ENBREL 4 25mg KIT with others for whom it was not prescribed. DO NOT USE ENBREL 4 25mg KIT for other health conditions. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full. IF YOU WILL BE USING ENBREL 4 25mg KIT FOR AN EXTENDED PERIOD OF TIME, be sure to obtain necessary refills before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.
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