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Are there any interactions with horse chestnut?

Horse chestnut is an herbal remedy made from an extract of the seeds, bark, and leaves of the horse chestnut tree. For centuries horse chestnut was used to treat various medical conditions.

Because horse chestnut contains chemicals that may thin the blood, do not use it if you take aspirin, warfarin (brand name Coumadin), ticlopidine (Ticlid), or clopidogrel (Plavix). Combining horse chestnut with these drugs may increase the risk of bleeding.

Sources:
Brinker, F. Herb Contraindications and Drug Interactions. Eclectic Medical Publications, 1998.
Peirce, A. The American Pharmaceutical Association Practical Guide to Natural Medicines. William Morrow & Co., 1999.
The Review of Natural Products. Facts and Comparisons, 2000.
Mashour, N., G. Lin, W. Frishman, Herbal medicine for the treatment of cardiovascular disease: clinical considerations. Archives of Internal Medicine. 158 (1998).
Argento A. "Oral anticoagulants and medicinal plants. An emerging interaction" Annuals of Italian Medicine Internal 15 (2000).
Heck AM. "Potential interactions between alternative therapies and warfarin" American Journal of Health Systems Pharmacist 57 (2000).

This answer prepared 2/20/01.

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