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What are the side effects of fish oil supplements?

The most commonly reported side effects of fish oil supplements include fishy odor on the breath, upset stomach, and greasy stools. A more serious side effect can be an increase in LDL cholesterol, a harmful form of cholesterol. Large doses of fish oil supplements may also cause weight gain and decrease the absorption of vitamins A, E, D, and K from the stomach. If you have diabetes, use caution when taking fish oil supplements, they are reported to increase blood sugar.

Taking large amounts of fish oils over a long period of time may increase the risk of mild bleeding resulting in nosebleeds and bruising.

It's not a good idea to use cod liver oil as a fish oil supplement because it contains very high levels of vitamin A. High doses of vitamin A can cause headache, dry skin, itching, and liver damage.

Sources:
Drug Facts and Comparisons. Facts & Comparisons, 2007.
Fasching, P. "Fish Oil Supplementation Versus Gemfibrozil Treatment in Hyperlipidemic NIDDM. A Randomized Crossover Study," Hormonal and Metabolic Research 28 (1996).
Gray, D.R. "Fish Oil As An Adjuvant in the Treatment of Hypertension," Pharmacotherapy 16 (1996).
Micromedex® Healthcare Series. Thomson Micromedex, 2007.

This answer prepared 4/20/2001.
This information updated 1/22/2007.

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