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What are the side effects of phentermine?

Phentermine (brand names Adipex-P, Ionamin) is a prescription drug used for weight loss. This medication works in the brain to decrease appetite. Dry mouth, nervousness, constipation, and nausea are the most commonly reported side effects of phentermine. More serious side effects include increased blood pressure and heart rate, anxiety, and blurred vision. You should have your blood pressure checked regularly while taking phentermine. Rarely, heart valve damage and a rare lung disorder called primary pulmonary hypertension (PPH) have been linked to the use of phentermine alone and in combination with certain weight loss medicines like dexfenfluramine (Redux) and fenfluramine (Pondimin). These combinations were more commonly known as the “phen-fen” diet.

You should not take phentermine if you have heart disease (coronary artery disease, congestive heart disease, irregular heartbeat, or stroke), thyroid disease, glaucoma, or anorexia. Phentermine is not recommended if you are pregnant or are considering pregnancy. If you have other medical conditions, you should discuss the use of phentermine with your physician.

Sources:
Micromedex Healthcare Series. Micromedex Inc., 1999.
Adipex-P product information, Teva Pharmaceuticals, Inc. 1998.
Drug Information Handbook. American Pharmaceutical Association, 1999.

This answer prepared 12/14/00.

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