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Is there a drug interaction between Prozac and Meridia?

A serious drug interaction can occur between Prozac (generic name >fluoxetine) and >Meridia (sibutramine), so don't take them together. These drugs work in similar ways to increase a chemical in the brain called serotonin. Too much serotonin can lead to a condition known as serotonin syndrome, which can include high blood pressure, low body temperature, severe muscle spasms, and unconsciousness.

Meridia may also interact with drugs that are similar to Prozac including >Paxil, >Zoloft, >Celexa, Effexor, and >Luvox.

Sources:
Micromedex® Healthcare Series. Thomson Micromedex, 2006.
Meridia product information Abbott Laboratories, Inc., 2006.
Drug Facts and Comparisons. Facts & Comparisons, 2006.

This answer prepared 8/13/2001.
This information updated 11/30/2006.

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