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Are there any drug interactions with Celebrex?

Celebrex (generic name celecoxib) is medication that can treat the pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Celebrex belongs to a class of nonsteroidal anti-inflammatory drugs (NSAIDs) known as COX-2 inhibitors. Celebrex and other COX-2 inhibitors are effective in treating pain and inflammation but are less likely to cause serious stomach side effects (stomach ulcers and bleeding, for example) than other NSAIDs such as ibuprofen (Motrin) and naproxen (Naprosyn).

Celebrex may interact with many other medicines to make them less effective or increase their side effects. Talk with your doctor or pharmacist about whether Celebrex interacts with other medicines you are taking.

Examples of drugs that may interact with Celebrex include other NSAIDs like aspirin, naproxen (brand names Aleve, Naprosyn) or ibuprofen (Advil, Motrin). Celebrex should also be used with caution in people taking medicines that prevent blood clotting such aswarfarin (Coumadin). Celebrex may also interact with lithium (Lithobid), fluconazole (Diflucan), and blood pressure medicines such as furosemide (Lasix), enalapril (Vasotec), and lisinopril (Zestril).

Sources:
Micromedex Healthcare Series. Micromedex Inc., 2001.
Celebrex Product Information, Searle, Inc., 1999.

This answer prepared 1/11/01.

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