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How do I choose a SAM-e product?

Your body makes SAM-e from an amino acid called methionine, which is commonly found in food. Cells in the body use SAM-e to make cartilage and repair cell damage. SAM-e, as a dietary supplement, is marketed for its ability to promote "joint health" and "emotional well being." The active ingredient in SAM-e is S-adenosylmethionine.

Choose an enteric-coated SAM-e tablet. The absorption of regular SAM-e tablets into the body is low because stomach acid destroys the active ingredient. Enteric coating may prevent stomach acid from destroying SAM-e, resulting in better absorption. You should also select a product that’s made by a reputable company. Several reliable enteric-coated products include Nature Made SAM-e or >GNC SAM-e.

Sources:
Grazi, S., M. Costa. SAMe (S-adenosylmethionine). Prima Publishing, 1999.
Kuhn, M.A. Herbs, Drugs & the Body. Medical Educational Services Inc., 1999.
Pepping, J. “Alternative Therapies: SAM-e: S-adenosylmethionine,” American Journal of Health-System Pharmacy V 57-2 (2000).
Drug Facts and Comparisons. Facts & Comparisons, 2007.

This answer prepared 3/8/2001.
This information updated 1/18/2007.

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