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What are the side effects of SAM-e?

SAM-e is a compound your body makes from an amino acid called methionine, which is commonly found in food. Cells in the body use SAM-e to make cartilage and repair cell damage. SAM-e, as a dietary supplement, is marketed for its ability to promote "joint health" and "emotional well being." The active ingredient in SAM-e is S-adenosylmethionine.

The reported side effects of SAM-e are mild, and occur infrequently. They include stomach upset, diarrhea, headaches, and nausea. If you are taking prescription medicines for depression, or if you have a bipolar disorder (also called manic depression), you should consult with your physician before using this product.

Sources:
Glorioso, S. "Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis," International Journal of Clinical Pharmacology Research 5 (1985).
Salmaggi, P. "Double-blind, placebo-controlled study of S-adenosyl-L-methionine in depressed postmenopausal women," Psychotherapy and Psychosomatics 59 (1993).
Grazi, S., M. Costa. SAMe (S-adenosylmethionine). Prima Publishing, 1999.
The Natural Medicines Comprehensive Database. Pharmacists Letter Inc., 2001.
Pepping, J. “Alternative Therapies: SAM-e: S-adenosylmethionine,” American Journal of Health-System Pharmacy V 57-2 (2000).

This answer prepared 3/8/01.

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