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 | Are there any interactions with SAM-e?
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|  SAM-e is a compound your body makes from an amino acid called methionine, which is commonly found in food. Cells in the body use SAM-e to make cartilage and repair cell damage. SAM-e, as a dietary supplement, is marketed for its ability to promote "joint health" and "emotional well being." The active ingredient in SAM-e is S-adenosylmethionine. You should not take SAM-e with the anticancer medicine cytosine arabinoside because SAM-e may lower its effectiveness. SAM-e may also interfere with some prescription antidepressant medicines like fluoxetine (brand name Prozac), sertraline (Zoloft), paroxetine (Paxil), and clomipramine (Anafranil). If you are taking a prescription medicine for depression or if you have a bipolar disorder, please consult your doctor before using SAM-e. Sources:
Grazi, S., M. Costa. SAMe (S-adenosylmethionine). Prima Publishing, 1999.
Rakasz, E. "Modulation of cytosine arabinoside-induced proliferation inhibition by exogenous adenosylmethionine," Cancer Chemotherapy and Pharmacology 28 (1991).
The Natural Medicines Comprehensive Database. Pharmacists Letter Inc., 2001.
Pepping, J. “Alternative Therapies: SAM-e: S-adenosylmethionine,” American Journal of Health-System Pharmacy V 57-2 (2000).
Drug Facts and Comparisons. Facts & Comparisons, 2007.
This answer prepared 3/8/2001.
This information updated 1/18/2007.
- Prozac
- >Zoloft
- >Paxil
- >Anafranil
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