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Can selective serotonin-reuptake inhibitors (SSRIs) cause sexual dysfunction?

There are several ways to regain normal sexual function while taking antidepressants. Sometimes normal sexual function returns on its own as antidepressant therapy is continued. Another approach is to reduce the antidepressant dose, although this should only be tried under the close supervision of your doctor. Changing to a different type of antidepressant drug is another option. Bupropion (Wellbutrin), nefazodone (Serzone), and mirtazapine (Remeron) are antidepressants with few or no reported sexual side effects.

If you're taking antidepressants and experiencing any symptoms of sexual dysfunction, talk with your doctor so that he or she can recommend appropriate changes in your medications.

References:Segraves, R .T. "Antidepressant-Induced Sexual Dysfunction," Journal of Clinical Psychiatry 59 (1998).Sussman, N. "The Role of Antidepressants in Sexual Dysfunction," Journal of Clinical Psychiatry Monograph 17 (1999).Gutierrez, M. "Management of and Counseling for Psychotropic Drug-Induced Sexual Dysfunction," Pharmacotherapy 19 (1999).Rosen, R. "Effects of SSRIs on Sexual Function: A Critical Review," Journal of Clinical Psychopharmacology 19 (1999).

This answer prepared 7/29/99.

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