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What are SSRIs?

SSRIs (selective serotonin reuptake inhibitors) are the most commonly prescribed antidepressant medications. They include citalopram (brand name Celexa), paroxetine (>Paxil), fluoxetine (>Prozac and Sarafem), and sertraline (>Zoloft). Doctors also prescribe SSRIs to treat people with anxiety disorders, eating disorders, certain types of nerve pain, and severe premenstrual syndrome (PMS).

SSRIs increase the amount of the chemical serotonin in the brain. Brain cells use serotonin to communicate with each other. Most scientists believe serotonin plays a role in depression and other mental conditions. .

SSRIs start to work within the first week of treatment, but it can take four to six weeks to see the full effects. All antidepressants, including SSRIs, are equally effective when used at the recommended doses. However, SSRIs are safer in situations of overdose than older antidepressants.

Sources:
Micromedex Healthcare Series. Micromedex Inc., 2000.
The American Psychiatric Press Textbook of Psychopharmacology. American Psychiatric Press Inc., 1998.
Sarafem Product Information. Eli Lilly & Company, July 2000.

This answer prepared 8/23/00.