 Prozac (generic name >fluoxetine) belongs to a family of medicines called selective serotonin reuptake inhibitors (SSRIs). Prozac is often used for depression, but may also be prescribed for other conditions including anxiety disorders and eating disorders. Sarafem is a drug recently approved for premenstrual dysphoric disorder (PMDD). It contains the same active ingredient as Prozac and Prozac Weekly (fluoxetine). For this reason, you should not take Prozac with Sarafem, Prozac Weekly or fluoxetine. Prozac may interact with several medications. Do not take Prozac in combination with sibutramine (brand name Meridia) or monoamine oxidase inhibitors (MAOI) such as tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl). This can cause side effects such as mood swings, restlessness, sweating, chills, and tremor. It can also lead to more severe problems including high blood pressure, fever, and seizures. Prozac can interact with other medicines including terfenadine (Seldane), astemizole (Hismanal), clarithromycin (Biaxin), tramadol (Ultram), and phenytoin (Dilantin). Also make sure your doctor knows if you are taking warfarin (Coumadin), digoxin (Lanoxin), tryptophan, sleeping pills, or tranquilizers. For some people, Prozac can increase the level of these medicines in the blood, causing side effects. Sources:
Micromedex Healthcare Series. Micromedex Inc., 2001.
USP-DI Advice for the Patient: Drug Information in Lay Language, Micromedex Inc., 2001.
Drug Facts and Comparisons, Facts and Comparisons, 2000.
Sarafem Product Information. Eli Lilly & Company, July 2000.
Prozac Product Information, Eli Lilly and Company. May 2001.
This answer prepared 8/13/01.
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