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Are there prescription treatments for fibromyalgia?

Doctors may prescribe a muscle relaxer called cyclobenzaprine (brand name Flexeril) alone or along with >ibuprofen (Motrin, Advil) to relieve pain and relax muscle spasms associated with fibromyalgia. For particularly tender areas, your doctor may inject a steroid medicine (such as Solu-Cortef) to help relieve pain and improve movement.

If you have depression or anxiety, an antidepressant or anti-anxiety medicine may help. Some people find that antidepressants can also help with sleep, daytime fatigue, and pain. >Amitriptyline (brand name Elavil) is the most widely studied antidepressant for people with fibromyalgia. More recently, doctors have been prescribing antidepressants such as fluoxetine (>Prozac), sertraline (>Zoloft), and paroxetine (>Paxil) for symptoms of depression, fatigue, and sleep problems. While these drugs offer short-term benefits, more studies are needed to determine how well they work over time.

Sources:
Arnold LM. “Antidepressant Treatment of Fibromyalgia. A Meta-analysis and Review,” Psychosomatics, 41 (2000).
Koopman WJ. Arthritis and Allied Conditions. Williams and Wilkins. 1997.
The Merck Manual of Medical Information: Home Edition. Merck & Co., 1997.
Alarcon GS, Bradley LA. "Advances in the Treatment of Fibromyalgia: Current Status and Future Directions." The American Journal of the Medical Sciences, 315 (1998).

This answer prepared 10/27/00.

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