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What is Synvisc?

Synvisc (generic name hylan G-F 20) is an injectable fluid used to treat osteoarthritis of the knee. It's classified as a medical device--which allows the manufacturer to promote Synvisc as a "drug-free" treatment.

Synvisc helps replenish the fluid inside the joint, thereby increasing the fluid's shock-absorbing ability and, ideally, reducing pain and stiffness. Doctors may give Synvisc when other treatments, such as nonprescription and prescription drugs, haven't worked. Clinical studies show that Synvisc improves movement and relieves joint pain and morning stiffness in 40 to 80 percent of people who use it.

Doctors usually give Synvisc injections in the office. The standard regimen is three injections spaced at weekly intervals. You may not notice improvement until six to 12 weeks after the first injection. Benefits may last up to three months after a single series of injections. In some cases, doctors may give more than one series of injections.

Sources:
Micromedex® Healthcare Series. Thomson Micromedex, 2007.
Synvisc product information. Genzyme Corporation, 2007.
Goorman, S.D. “Functional Outcome in Knee Osteoarthritis After Treatment with Hylan G-F 20: a Prospective Study”. Archives of Physical and Medical Rehabilitation 81 (2000).

This answer prepared 5/17/2000.
This information updated 1/17/2007.