 Proton pump inhibitors (PPIs) are a group of prescription medications that prevent the release of acid in the stomach and intestine. Doctors prescribe PPIs to treat people with heartburn (acid reflux), ulcers of the stomach or intestine, or excess stomach acid (Zollinger-Ellison Syndrome). PPIs include rabeprazole (brand name Aciphex), lansoprazole (Prevacid), and omeprazole (Prilosec). Most people tolerate PPIs well with few side effects. The most common side effects include mild dizziness, headache, nausea, diarrhea, and rash. Rare side effects are breast enlargement in men and anemia. This answer prepared 10/1/1999. References:
Aciphex product information, Eisai Co., 1999.
Micromedex Healthcare Series. Micromedex, Inc., 1999.
Prevacid product information, TAP Pharmaceuticals, Inc., 1998.
Prilosec product information, Astra Pharmaceuticals, 1998.
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