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Are there any interactions with proton pump inhibitors ?

Proton pump inhibitors (PPIs) are a group of prescription medications that prevent the release of acid in the stomach and intestine. Doctors prescribe PPIs to treat people with heartburn (acid reflux), ulcers of the stomach or intestine, or excess stomach acid (Zollinger-Ellison Syndrome). PPIs include rabeprazole (brand name Aciphex), lansoprazole (Prevacid), and omeprazole (Prilosec).

PPIs can interact with ketoconazole (Nizoral tablets) and itraconazole (Sporanox), making them less effective as antifungal medications. PPIs can also interact with phenytoin (Dilantin) and warfarin (Coumadin) to make side effects of these drugs more likely or more severe. Doctors often monitor people closely when they take PPIs along with these drugs.

This answer prepared 10/1/1999.

References:
Micromedex Healthcare Series. Micromedex, Inc., 1999.
Hansten, P.D., J.R. Horn. Drug Interactions Analysis and Management. Applied Therapeutics, 1999.

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