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Are there any prescription treatments for wrinkles?

Wrinkles result from the breakdown of collagen and elastin, proteins that keep the skin smooth and supple. Aging and sun damage are the main culprits in causing wrinkles. Smoking is also a factor, because it reduces blood flow to the skin.

Tretinoin (brand names Renova and >Retin-A) is a prescription drug that helps to minimize wrinkles. It works by increasing the amount of elastin in the skin to smooth the skin's appearance. Medical research has shown that about 60 percent of people who use tretinoin see mild to moderate improvement in fine wrinkles, sunspots, and rough skin. Tretinoin doesn't actually eliminate wrinkles and has little effect on deep ones. You must use these products daily for at least three to four months to notice an effect, and six to nine months to see the greatest difference. The benefits of tretinoin usually go away after you stop using it.

Over-the-counter remedies containing alpha hydroxy acids such as Alpha Hydrox are also available for wrinkles. To prevent wrinkles, avoid excess exposure to the sun. Wear sunscreen or protective clothing when you're outdoors in direct sunlight for more than a few minutes. Not smoking can also help prevent wrinkles.

Sources:
Renova Product Information. Ortho Neutrogena. Last accessed 1/2/2007.
Habif, Thomas. Clinical Dermatology. Mosby-Year Book Inc., 1996.
Micromedex® Healthcare Series. Thomson Micromedex, 2007.
Grady, D. "Does Cigarette Smoking Make You Ugly and Old?," American Journal of Epidemiology 135 (1992).
Drug Facts and Comparisons. Facts & Comparisons, 2007.
Medline Plus. Medline, 2007.

This answer prepared 5/23/2000.
This information updated 1/2/2007.