ask your pharmacist

Are there any drug interactions with Depakote

Taking Depakote together with other seizure medicines like carbamazepine (brand name Tegretol), phenytoin (Dilantin), lamotrigine (Lamictal), or phenobarbital can either raise or lower the amount of Depakote in the body. Make sure your doctor knows if you're taking one of these medicines. Your doctor can use blood tests to monitor Depakote levels in your body and adjust the dosage if needed.

It's also important for your doctor to know if you're taking other drugs including chlorpromazine (Thorazine), cimetidine (Tagamet), isoniazid, rifampin (Rifadin), felbamate (Felbatol), erythromycin (Ery-Tab), or aspirin. These drugs can trigger side effects by raising Depakote levels in the body. Here again you may need your Depakote dose adjusted to prevent side effects.

Depakote can also increase levels of other drugs in the body, including diazepam (Valium), ethosuximide (Zarontin), warfarin (Coumadin), and zidovudine (Retrovir). Talk to your doctor before taking these medicines with Depakote.

Sources:
Hansten, P.D., J.R. Horn. Drug Interactions Analysis and Management. Applied Therapeutics, 2000.
Micromedex® Healthcare Series. Thomson Micromedex, 2006.
Drug Facts and Comparisons. Facts & Comparisons, 2006.
Medline Plus. Medline, 2006.

This answer was prepared 11/17/2000.
This information updated 2/7/2007.

• >carbamazepine
• >phenytoin
• >lamotrigine
• >Lamictal
• >phenobarbital
• >chlorpromazine
• >Thorazine
• >cimetidine
• >Rifadin
• >felbamate
• >erythromycin
• >diazepam
• >ethosuximide
• >warfarin
• >zidovudine