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What is baclofen?

Baclofen (brand name Lioresal) is a medicine used to treat the muscle spasms, cramping, and tightness that affect many people with multiple sclerosis, spinal cord conditions, or tardive dyskinesia. It relaxes muscles by acting on the brain and spinal cord.

Baclofen comes in tablet and injectable forms. The proper dose is determined by the person's medical condition and how the person responds to the drug. Doctors often start people on a low dose and gradually increase it every three days until achieving the desired effect. The muscle- relaxing effects usually occur within the first three to four days.

Do not stop taking baclofen abruptly. This can cause anxiety, agitation, seizures, or hallucinations. It's best to gradually withdraw the drug over one to two weeks.

Sources:
Drug Facts and Comparisons. Facts & Comparisons, 2006.
Drug Information Handbook. American Pharmaceutical Association, 1999.
Micromedex® Healthcare Series. Thomson Micromedex, 2006.
USP-DI Advice for the Patient: Drug Information in Lay Language. Micromedex Inc., 1998

This answer prepared 8/8/2000.
This information updated 1/25/2007