Learn more about usage, cautions, and possible side effects .
Chemical Name: ESTRADIOL (ess-tra-DYE-ole)
This medicine is a female hormone usually given to women who no longer are able to produce the proper amount of hormone (i.e., estrogen). This medicine is used to treat the vaginal and urinary symptoms of menopause.
WARNING: Estrogens have been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause, especially in women with a uterus who receive estrogen-only hormone therapy. Estrogens may also increase the risk of cancer of the ovary or breast. Estrogen-containing products should not be used to prevent heart disease. Estrogen given in combination with another hormone (progestin) for replacement therapy can infrequently cause heart disease (e.g., heart attacks), stroke, serious blood clots (pulmonary embolism and deep venous thrombosis), and cancer of the breast. These risks appear to depend on the length of time this drug is used and the amount of estrogen per dose. Therefore, this medicine should be used for the shortest possible length of time at the lowest effective dose so you obtain the benefits and minimize the chance of serious side effects from long-term treatment. Consult your doctor or pharmacist for details. If you use this medicine for an extended period, you should be evaluated at least once a year. See CAUTIONS section. This medicine is not effective in preventing or treating a tendency toward miscarriages (natural habitual abortion), nor the threat of miscarriage. This medicine must not be used during pregnancy because its use may result in birth defects or cancer later in the child's life. See CAUTIONS section. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are using other vaginal products. Consult your doctor or pharmacist for more information. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have undiagnosed abnormal vaginal bleeding, certain cancers (e.g., breast cancer, especially non-metastatic type), blood clots, active or recent stroke, or heart attack. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you have a family history (especially breast lumps and cancer), asthma, diabetes, seizures, migraine headaches, liver disease, heart disease (e.g., high blood pressure, heart attacks, congestive heart failure), kidney disease, low thyroid hormone (hypothyroidism), abnormal calcium level in the blood, depression, high blood pressure during pregnancy (toxemia), yellowing of eyes and skin (cholestatic jaundice) during pregnancy or with past estrogen use, womb problems (e.g., uterine fibroids, endometriosis), vaginal conditions (e.g., recurring vaginal infections, prolapse, stenosis), cholesterol or lipid problems, gallbladder disease, excessive weight gain, or certain blood disorders (porphyria). Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.
Follow the directions for using this medicine provided by your doctor. THIS MEDICINE comes with an instruction leaflet. Read it carefully. Learn all usage instructions in the product package. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. Insert the ring into the upper third of the vagina as directed. Generally, the ring is left in place for 90 days and then removed and replaced with a new ring if therapy is continued. DO NOT leave the ring in place for longer than 90 days. Follow the dosing schedule carefully. When properly placed, you should not feel the ring and it will not interfere with sexual intercourse. If the ring moves into the lower part of your vagina, push it back into place with your finger. If the ring falls out of the vagina, rinse the ring with lukewarm water and re-insert. The ring is removed by hooking your finger through the ring and gently pulling it out. It is recommended that the ring be removed during treatment with other vaginal medicines. If you develop a vaginal infection while using the ring, it is recommended that you remove the ring and resume therapy after the infection has been treated. Consult your doctor or pharmacist for more information. Discard the used ring in the trash container. DO NOT FLUSH it down the toilet. STORE THIS MEDICINE at room temperature between 59 and 86 degrees F (15 and 30 degrees C), away from heat, moisture, and light. IF YOU FORGET AND HAVE NOT inserted a new ring after 90 days, contact your doctor to establish a new schedule for this medicine.
IT MAY TAKE 2 TO 3 WEEKS for this medicine to work. If your symptoms persist, contact your doctor. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. You should have a complete physical examination, including blood pressure measurements, breast and pelvic examinations, and a PAP test (for vaginal cancer), at least once a year. You should also have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately. BEFORE HAVING SURGERY, or being confined to a bed or chair for long periods of time (e.g., a long plane flight), tell your doctor that you are using this medicine. Special precautions may be needed in these circumstances while using this medicine. THIS MEDICINE MAY CAUSE DIZZINESS. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. Limit alcohol while using this medicine. CERTAIN LAB TEST RESULTS may be affected by this medicine. Make sure your doctors and laboratory personnel know that you are using this medicine. THIS MEDICINE MAY CAUSE dark skin patches on your face (melasma). Exposure to the sun may make these patches darker. Consult your doctor regarding use of sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths. SMOKING WHILE USING THIS MEDICINE may increase your risk of blood clots (especially in women over the age of 35). DO NOT USE THIS MEDICINE if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.
SIDE EFFECTS, that may go away during treatment, include vaginal discomfort, increased vaginal discharge, dizziness, lightheadedness, headache, stomach upset, bloating, nausea, weight changes, increased or decreased interest in sex, or breast tenderness. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience mental or mood changes (e.g., severe depression); calf pain or swelling; sudden severe headache; chest pain; trouble breathing; one-sided weakness; slurred speech; vision changes (e.g., change in contact lens fit, loss of vision); breast lumps; swelling of hands or feet; changes in vaginal bleeding (e.g., spotting, breakthrough bleeding or prolonged bleeding); unusual vaginal discharge, itching, or odor; yellowing of eyes or skin. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice any other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include severe nausea or vomiting, or excessive vaginal bleeding. This medicine may be harmful if swallowed.
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children and pets. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
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