Learn more about usage, cautions, and possible side effects .
Chemical Name: GLYBURIDE (GLYE-bure-ide) and METFORMIN (met-FOR-min)
This medicine is a sulfonylurea and biguanide antidiabetic combination used along with diet and exercise to treat type 2 diabetes. It may be used alone or with other antidiabetic medicines.
WARNING:THE METFORMIN IN THIS◙COMBINATION MEDICINE MAY RARELY CAUSE A SERIOUS AND SOMETIMES FATAL CONDITION CALLED◙LACTIC ACIDOSIS.Most of these cases have occurred in diabetic patients who also have certain kidney◙problems.The risk of lactic acidosis may be greater if you have liver problems,kidney problems, or◙heart failure.The risk may also be greater in patients who are elderly or drink alcohol.Lab tests,◙including kidney function,may be performed while you take this medicine.DO NOT begin to take this◙medicine if you are older than 80 years old unless lab tests show that you do not have decreased◙kidney function.DO NOT take it if you have a severe infection,have low blood oxygen levels,or are◙dehydrated.Tell your doctor you take this medicine before you have any surgery or lab◙procedures.Contact your doctor right away if younotice symptoms such as fast or difficult◙breathing;muscle pain or tenderness;slow or irregular heartbeat;unusual drowsiness,dizziness,or◙lightheadedness;unusual stomach discomfort;or unusual weakness or tiredness.Contact your doctor◙right away if you start to feel unusually cold or if you have a general feeling of being unwell.Some◙medicines or medical conditions may interact with this medicine.INFORM YOUR DOCTOR OR◙PHARMACIST of all prescription and over-the-counter medicine that you are taking.DO NOT TAKE◙THIS MEDICINE IF you are taking bosentan.Some MEDICINES MAY INTERACT with this◙medicine.ADDITIONAL MONITORING OR YOU DOSE OR CONDITION may be needed if you are taking◙beta-blockers(eg,propranolol);anticoagulants (eg,warfarin);azole antifungals◙(eg,miconazole);chloramphenicol;clarithromycin;clofibrate;fenfluramine;insulin;monoamine◙oxidase inhibitors (MAOIs) (eg,phenelzine);nonsteroidal anti-inflammatory drugs (NSAIDs)◙(eg,ibuprofen);phenylbutazone;probenecid;quinolones (eg,ciprofloxacin);salicylates◙(eg,aspirin);sulfonamides (eg,sulfamethoxazole);thiazolidinediones (eg,pioglitazone);calcium◙channel blockers (eg,nifedipine);corticosteroids (eg,prednisone);diazoxide;diuretics◙(eg,furosemide,hydrochlorothiazide);estrogen;hormonal contraceptives (eg,birth control◙pills);isoniazid;nicotinic acid;phenothiazines◙(eg,chlorpromazine);phenytoin;rifampin;sympathomimetics◙(eg,albuterol,pseudoephedrine);thyroid hormones◙(eg,levothyroxine);gemfibrozil;amiloride;cimetidine;digoxin;morphine;procainamide;quinidine;qui◙nine;ranitidine;triamterene;trimethoprim;vancomycin; orcyclosporine.DO NOT START OR STOP◙any medicine without doctor or pharmacist approval.Inform your doctor of any other medical◙conditions,including if you have a history of heart problems (eg,heart attack,heart failure);blood◙vessel problems;lung or breathing problems;thyroid problems;stomach or bowel problems◙(eg,blockage,paralysis);adrenal or pituitary problems;lactic acidosis;type 1◙diabetes;vomiting;diarrhea;poor health or nutrition;low blood calcium or vitamin B12◙levels;anemia;glucose-6-phosphate dehydrogenase deficiency;an infection;fever;recent◙injury;moderate to severe burns;allergies;pregnancy;or breast-feeding.Tell your doctor if you drink◙alcohol or have a history of alcohol abuse;will be having surgery or certain lab procedures;you are◙dehydrated;or if you take a beta-blocker(eg,propranolol).USE OFTHIS MEDICINE IS NOT◙RECOMMENDED if you have a severe infection;low blood oxygen levels;kidney or liver problems;high◙blood ketone or acid levels (eg,diabetic ketoacidosis);severe dehydration;a stroke or a recent heart◙attack;are in shock;are 80 years old or older and have not had a kidney function test;or if you will be◙having surgery or certain lab procedures.Use of this medicine in children under age 9 is not◙recommended;safety and effectiveness in these children have not been confirmed.Contact your◙doctor or pharmacist if you have any questions or concerns about using this medicine.
Follow the directions for taking this medicine provided by your doctor. AN EXTRA PATIENT LEAFLET is available with this medicine. Talk to your pharmacist if you have questions about this information. TAKE THIS MEDICINE BY MOUTH WITH MEALS. HIGH AMOUNTS OF DIETARY FIBER may decrease this medicine's effectiveness, resulting in high blood sugar. If you have questions about including fiber in your diet while you are taking this medicine, talk with your doctor. STORE THIS MEDICINE at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Do NOT TAKE MORE THAN THE RECOMMENDED DOSE without checking with your doctor. Take this medicine on a regular schedule to get the most benefit from it. Taking this medicine at the same time each day will help you remember to take it. CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses. IF YOU MISS A DOSE of this medicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
DO NOT USE THIS MEDICINE IF you are allergic to any ingredient in this medicine. LAB TESTS may be performed while you use this medicine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. THIS MEDICINE MAY CAUSE DIZZINESS; it may be worse if you take it with alcohol or certain medicines. Do not drive or perform other possibly unsafe tasks until you know how you react to it. DO NOT DRINK ALCOHOL while you use this medicine. Alcohol may increase the risk of this medicine's side effects and may rarely interact with this medicine and cause a serious reaction (eg, flushing, nausea, vomiting, dizziness, stomach pain). Talk with your doctor or health care provider before you drink alcohol while you use this medicine. TELL YOUR DOCTOR OR DENTIST that you take this medicine before you receive any medical or dental care, emergency care, or surgery. THIS MEDICINE CONTAINS A SULFONYLUREA. It may increase the risk of death from heart disease. Talk with your doctor about the benefits and risks of this or other therapies to treat your condition. THIS MEDICINE MAY CAUSE LOW BLOOD SUGAR LEVELS. Low blood sugar symptoms include anxiety; sweating; weakness; dizziness; drowsiness; fainting; fast heartbeat; vision changes; headache; chills; tremor; increased hunger. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar (eg, table sugar, orange juice). Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals. Risk of low blood sugar may be increased by heavy or prolonged exercise. FEVER, INFECTION, INJURY, OR SURGERY MAY INCREASE YOUR RISK for high or low blood sugar levels. If any of these occur, check your blood sugar closely and tell your doctor right away. THIS MEDICINE MAY COMMONLY CAUSE stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems or stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis. BE CAREFUL NOT TO BECOME DEHYDRATED; this may increase your risk of side effects from this medicine. BEFORE YOU BEGIN TAKING ANY NEW MEDICINES, either prescription or over-the-counter, check with your doctor or pharmacist. Use this medicine with caution in the ELDERLY; they may be more sensitive to its effects. FOR WOMEN: IF YOU BECOME PREGNANT, contact your doctor. You will need to discuss the benefits and risks of using this medicine while you are pregnant. IF YOU TAKE THIS MEDICINE DURING PREGNANCY, do not take it within 2 weeks of the expected delivery date without first checking with your doctor. It is not known if this medicine is found in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you use this medicine, check with your doctor. Discuss any possible risks to your baby.
SIDE EFFECTS that may occur while taking this medicine include diarrhea; headache; indigestion; mild stomach pain; nausea; stomach upset; or vomiting. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience chest pain or discomfort; confusion; dark urine; dizziness or lightheadedness; fainting; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; low blood sugar symptoms (eg, anxiety, dizziness, fast heartbeat, headache, tremors, unusual sweating); muscle pain or weakness; severe or persistent blurred vision or other vision problems; slow or irregular heartbeat; unusual bruising or bleeding; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness; or yellowing of the eyes or skin. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include coma; confusion; dizziness or lightheadedness; fainting; fast or difficult breathing; fast, slow, or irregular heartbeat; feeling of being unusually cold; general feeling of being unwell; muscle pain or tenderness; seizures; tremor; unusual drowsiness; unusual stomach discomfort; or unusual weakness or tiredness.
This medicine is not a substitute for proper diet and regular exercise. It is recommended you attend a diabetes education program to better understand diabetes, prevention of complications, and all the important aspects of its treatment. These include meals/diet, exercise, weight loss, personal hygiene, medicine and blood glucose monitoring, and the need for regular eye, foot, and medical exams. Follow your doctor's instructions carefully. Carry an identification card at all times that says you are diabetic. Monitor your blood sugar levels regularly according to your doctor's directions. If your blood sugar level is often higher or lower than it should be and you are taking this medicine according to directions, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. KEEP THIS MEDICINE out of the reach of children and pets. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
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