Learn more about usage, cautions, and possible side effects .
Chemical Name: LISINOPRIL (lye-SIN-oh-pril) and HYDROCHLOROTHIAZIDE (HYE-droe-KLOR-oh-THYE-a-zide)
This medicine is an angiotensin converting enzyme (ACE) inhibitor and thiazide diuretic combination used to treat high blood pressure. It may also be used to treat other conditions as determined by your doctor.
WARNING: This medicine may cause injury or death to the fetus if taken during pregnancy. If you think you may be pregnant, contact your doctor right away. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE IF you are pregnant or if you are taking dofetilide or ketanserin. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking aldosterone blockers (eg, eplerenone); corticosteroids (eg, prednisone); digoxin; lithium; loop diuretics (eg, furosemide); potassium preparations; potassium-sparing diuretics (eg, triameterene); trimethoprim; barbiturates (eg, phenobarbital); dextran sulfate; diazoxide; narcotic pain medicine (eg, codeine); gold-containing medicines (eg, sodium aurothiomalate); nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib); salicylates (eg, aspirin); insulin; sulfonylureas (eg, glyburide); or other medicines for diabetes (eg, metformin). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including if you have impaired liver function; blood vessel problems (eg, stroke); heart disease (eg, congestive heart failure); high cholesterol; a history of kidney artery narrowing or decreased kidney function; gout; diabetes; electrolyte imbalances (eg, high or low potassium levels, low blood sodium levels); a collagen vascular disorder (eg, lupus, scleroderma); bone marrow problems; severe immune system problems; a history of allergies or asthma; pregnancy; or breast-feeding. Tell your doctor if you are on a sodium-restricted diet; on dialysis; or you have had a kidney transplant. Tell your doctor if you are able to become pregnant, or if you are scheduled to have major surgery or receive anesthesia. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of angioedema (swelling of the face, lips, throat, or tongue); a history of kidney artery narrowing; or you are unable to urinate. Use of this medicine in children is not recommended. Discuss with your doctor the risks and benefits of giving this medicine to your child. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.
Follow the directions for taking this medicine provided by your doctor. TAKE THIS MEDICINE with or without food. IF YOU TAKE CHOLESTYRAMINE OR COLESTIPOL, ask your doctor or pharmacist how to take it with this medicine. STORE THIS MEDICINE at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container away from heat, moisture, and light. Do not store in bathroom. Take this medicine on a regular schedule to get the most benefit from it. Taking this medicine at the same time each day will help you remember to take it. Continue to use this medicine even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.
DO NOT USE THIS MEDICINE IF you are allergic to any ingredient in this medicine or any other sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid). DO NOT EXCEED THE RECOMMENDED DOSE without checking with your doctor. THIS MEDICINE MAY CAUSE DIZZINESS, LIGHTHEADEDNESS, OR FAINTING; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. These effects may be worse if you take it with alcohol or certain medicines. Use this medicine with caution. DO NOT DRIVE OR PERFORM OTHER POSSIBLY UNSAFE TASKS until you know how you react to it. Lab tests, including blood electrolytes, blood pressure, complete blood cell counts, and kidney function, may be performed to monitor your condition or check for side effects. KEEP ALL DOCTOR AND LAB APPOINTMENTS while you are taking this medicine. Tell your doctor or dentist that you take this medicine before you receive any medical or dental care, emergency care, or surgery. THIS MEDICINE MAY INTERFERE WITH CERTAIN LAB TESTS, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking this medicine. CHECK WITH YOUR DOCTOR before you use a salt substitute or a product that has potassium in it. DRINK PLENTY OF FLUIDS while taking this medicine and avoid engaging in activities that cause excessive sweating. DEHYDRATION, EXCESSIVE SWEATING, VOMITING, OR DIARRHEA may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur. A PERSISTENT, UNPRODUCTIVE COUGH MAY OCCUR. Tell your doctor if this occurs. Recovery is rapid when the medicine is stopped. PATIENTS WHO TAKE MEDICINE FOR HIGH BLOOD PRESSURE often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal". Tell your doctor if you develop any new symptoms. THIS MEDICINE MAY NOT WORK AS WELL IN BLACK PATIENTS. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse. THIS MEDICINE MAY CAUSE YOU TO BECOME SUNBURNED MORE EASILY. Avoid the sun, sunlamps, or tanning booths until you know how you react to this medicine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. BEFORE YOU BEGIN TAKING ANY NEW MEDICINES, either prescription or over-the-counter, check with your doctor or pharmacist. Use this medicine with caution in the ELDERLY; they may be more sensitive to its effects. FOR WOMEN: THIS MEDICINE MAY CAUSE BIRTH DEFECTS OR FETAL DEATH if you take it while you are pregnant. IF YOU THINK YOU MAY BE PREGNANT, contact your doctor right away. THIS MEDICINE IS FOUND in breast milk. DO NOT BREAST-FEED while taking this medicine. DIABETES PATIENTS: This medicine may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
SIDE EFFECTS that may occur while taking this medicine include dizziness; headache; lightheadedness; nausea; persistent nonproductive cough; tiredness; or vomiting. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience chest pain or discomfort; confusion; dark urine; fainting; fast, slow, or irregular heartbeat; increased thirst; joint pain, stiffness, or swelling; muscle cramps or weakness; numbness or tingling of hands or feet; persistent and unusual stomach pain; persistent sore throat or fever; red, swollen, or blistered skin; severe dizziness or lightheadedness; shortness of breath; sudden unusual weight loss or gain; trouble swallowing; unusual bruising or bleeding; unusual or severe weakness or tiredness; vision changes; or yellowing of the skin or eyes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include dizziness, fainting, and weakness.
BE SURE TO KNOW YOUR GOAL BLOOD PRESSURE. Check your blood pressure regularly. Keeping your blood pressure under control is important to help lower the risk of heart, kidney, and blood vessel problems. If your blood pressure is often higher than it should be and you are taking this medicine according to directions, tell your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children and pets. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
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