Learn more about usage, cautions, and possible side effects .
Chemical Name: LANSOPRAZOLE (lan-SOE-pra-zole) and NAPROXEN (na-PROX-en)
This product contains two different medicines, lansoprazole and naproxen. This combination is used to treat the signs and symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis in patients who have had a stomach ulcer condition in the past. Naproxen is a nonsteroidal anti-inflammatory medicine used to treat many conditions associated with inflammation. Use of naproxen has been associated with an increased risk for stomach ulcers. Lansoprazole is a proton pump inhibitor used to reduce the amount of acid the stomach produces. Together, these medicines may provide the benefits of naproxen while protecting the stomach from excess acid production. This may reduce the risk of new ulcers associated with the use of naproxen. This medicine may be used to treat other conditions as determined by your doctor.
WARNING: THIS MEDICINE CONTAINS A NONSTEROIDAL ANTI-INFLAMMATORY DRUG (NSAID). IT MAY CAUSE AN INCREASED RISK OF SERIOUS AND SOMETIMES FATAL HEART AND BLOOD VESSEL PROBLEMS (such as heart attack, stroke). The risk may be greater if you already have heart problems or if you take this medicine for a long time. Do not use this medicine right before or after bypass heart surgery. THIS MEDICINE MAY CAUSE AN INCREASED RISK OF SERIOUS AND SOMETIMES FATAL STOMACH ULCERS AND BLEEDING. Elderly patients may be at greater risk. This may occur without warning signs. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking other forms of naproxen or HIV protease inhibitors (such as atazanavir). ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking anticoagulants (such as warfarin), aspirin, clopidogrel, corticosteroids (such as prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (such as fluoxetine), clarithromycin, probenecid, voriconazole, cyclosporine, digoxin, hydantoins (such as phenytoin), lithium, methotrexate, quinolones (such as ciprofloxacin), sulfonamides (such as sulfamethoxazole), sulfonylureas (such as glipizide), ampicillin, angiotensin-converting enzyme (ACE) inhibitors (such as enalapril), azole antifungals (such as ketoconazole), beta-blockers (such as propranolol), diuretics (such as furosemide, hydrochlorothiazide), iron, or theophylline. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including poor health; dehydration or low fluid volume; low blood sodium levels; alcohol or tobacco use; or a history of heart problems (such as heart failure or heart attack); blood vessel disease; blood disorders; bleeding or clotting problems; high blood pressure; stroke; swelling of the hands, feet, or ankles (edema); diabetes; stomach or bowel problems (such as bleeding, perforation, ulcers, or cancer); kidney problems; liver problems; asthma; growths in the nose (nasal polyps); mouth inflammation; alcohol abuse; allergies; pregnancy; or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have history of moderate to severe kidney disease, if you are going to have or have recently had coronary artery "heart bypass" (CABG) surgery, or if you are in the last 3 months of pregnancy. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.
Follow the directions for using this medicine provided by your doctor. This medicine comes with a MEDICATION GUIDE approved by the U.S. Food and Drug Administration. Read it carefully each time you refill this medicine. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. Take this medicine before eating unless your doctor tells you otherwise. NAPROXEN MAY BE TAKEN WITH FOOD if it upsets your stomach. Taking it with food may not decrease the risk of stomach or bowel problems (such as bleeding or ulcers) that may occur while taking this medicine. Talk with your doctor or pharmacist if you experience persistent stomach upset. SWALLOW the lansoprazole capsule whole. Do not break, crush, or chew before swallowing. Take this medicine with a full glass of water (8oz/240 mL). Do NOT lie down for 30 minutes after taking naproxen. If you are unsure how to properly take these medicines, ask your pharmacist for instructions. If you take an imidazole antifungal (such as ketoconazole), take it at least 2 hours before taking the lansoprazole. If you take antacids, sucralfate, or cholestyramine, ask your doctor or pharmacist how to take them with this medicine. STORE THIS MEDICINE at room temperature at 77 degrees F (25 degrees C) in the original container away from light and moisture. Brief storage between 59 and 86 degrees F (15 to 30 degrees C) is permitted. Use this medicine regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
DO NOT TAKE THIS MEDICINE IF YOU HAVE HAD A SEVERE ALLERGIC REACTION to aspirin or any medicine containing aspirin or a nonsteroidal anti-inflammatory drug (such as ibuprofen or celecoxib). A severe reaction includes a severe rash, hives, trouble breathing, growths in the nose, or dizziness. If you have a question about whether you are allergic to this medicine or if a certain medicine is a nonsteroidal anti-inflammatory drug, contact your doctor or pharmacist. DO NOT EXCEED THE RECOMMENDED DOSE or take this medicine for longer than prescribed without checking with your doctor. Laboratory and/or medical tests, including kidney or liver function may be performed to monitor your progress or to check for side effects, especially if you are taking this medicine for a long period of time. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. THIS MEDICINE MAY ALTER CERTAIN LAB TEST RESULTS. Make sure laboratory personnel and your doctors know you use this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. Serious stomach ulcers or bleeding can occur with the use of an NSAID. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. This medicine may cause drowsiness or dizziness. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. THIS MEDICINE CONTAINS NAPROXEN. Do not take ibuprofen, aspirin, or additional naproxen without checking with your doctor or pharmacist. Ask your pharmacist if you have questions about which medicines contain naproxen. THIS MEDICINE SHOULD BE USED WITH CAUTION IN ASIAN patients because the risk of side effects may be increased in these patients. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of this medicine, especially stomach bleeding and kidney problems. FOR WOMEN: THIS MEDICINE MAY CAUSE HARM to the human fetus. Do not use it during the last 3 months of pregnancy. IF YOU SUSPECT THAT YOU COULD BE PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. This medicine should not be used during labor. THIS MEDICINE IS EXCRETED IN BREAST MILK. Do not breast-feed while taking this medicine.
SIDE EFFECTS, that may occur while taking this medicine include constipation, diarrhea, dizziness, drowsiness, gas, headache, heartburn, nausea, or stomach upset. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience ringing in the ears, or unusual tiredness or weakness. CONTACT YOUR DOCTOR IMMEDIATELY if you experience bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; vision, hearing, or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes. AN ALLERGIC REACTION to this medicine is unlikely but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea or severe stomach pain, coffee ground-like vomit, decreased urination, unusual bruising or bleeding, slow or troubled breathing, severe dizziness or drowsiness, loss of consciousness, and seizures.
If your symptoms do not improve or if they become worse, contact your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children and pets. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
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