Learn more about usage, cautions, and possible side effects .
Chemical Name: AMITRIPTYLINE (a-mee-TRIP-ti-leen) and CHLORDIAZEPOXIDE (klor-dye-az-e-POX-ide)
This medicine is a tricyclic antidepressant and benzodiazepine combination used to treat anxiety and depression. It may also be used to treat other conditions as determined by your doctor.
WARNING: ANTIDEPRESSANTS MAY INCREASE THE RISK OF SUICIDAL THOUGHTS OR ACTIONS in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using this medicine outweigh the risks. Family and caregivers must closely watch patients who take this medicine. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking astemizole, cisapride, terfenadine, or tramadol. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking antifungal agents (imidazoles), carbamazepine, cimetidine, clonidine, clozapine, dicumarol, fluoxetine, fluvoxamine, guanadrel, guanethidine, guanfacine, macrolide antibiotics, mibefradil, monoamine oxidase inhibitors (MAOIs), nefazodone, paroxetine, phenothiazines, rifampin, or medicine for seizures. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including any mental or mood disorders (such as bipolar disorder), kidney disease, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of irregular heartbeat. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.
Follow the directions for taking this medicine provided by your doctor. This medicine comes with a medication guide. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. STORE THIS MEDICINE at room temperature in a tightly-closed container, away from heat and light. IF YOU MISS A DOSE OF THIS MEDICINE, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
SEVERAL DAYS TO WEEKS may pass before you feel the full effect of this medicine. Do not stop taking this medicine without checking with your doctor. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while taking this medicine. CHILDREN, TEENAGERS, AND ADULTS WHO TAKE THIS MEDICINE MAY BE AT INCREASED RISK FOR SUICIDAL THOUGHTS OR ACTIONS. Watch all patients who take this medicine closely, especially at the start of treatment with this medicine and whenever a change in dose is made. CONTACT THE DOCTOR AT ONCE if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. CONTACT YOUR DOCTOR AT ONCE if any signs of suicidal thoughts or actions occur. THIS MEDICINE MAY CAUSE drowsiness or dizziness. If dizziness occurs, sit up or stand up slowly. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine. THIS MEDICINE WILL ADD TO THE EFFECTS of alcohol and other depressants. Do not drink alcohol while you are taking this medicine without first checking with your doctor. Ask your pharmacist if you have questions about which medicines are depressants. ALCOHOL, HOT WEATHER, EXERCISE, AND FEVER can increase dizziness. To prevent dizziness or fainting, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness or weakness. THIS MEDICINE MAY CAUSE increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to this medicine. Use a sunscreen or protective clothing if you must be outside for a prolonged period. DO NOT BECOME OVERHEATED in hot weather or during exercise or other activities since heatstroke may occur. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. FOR WOMEN: THIS MEDICINE HAS BEEN SHOWN TO CAUSE HARM to the human fetus. IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine. Caution is advised when using this medicine in the elderly since they may be more sensitive to the effects of the medicine.
SIDE EFFECTS, that may go away during treatment, include drowsiness, dizziness, dry mouth, constipation, unpleasant taste, increased appetite especially for sweets, blurred vision, or headache. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience unsteadiness on your feet, increased tiredness, double vision, or confusion. CONTACT YOUR DOCTOR IMMEDIATELY if you experience severe nervousness or anxiety, agitation, panic attacks, difficulty sleeping, feelings of irritability or hostility, impulsive behavior or other unusual changes in behavior, severe restlessness, worsening feelings of depression, thoughts of hurting yourself, or any other mental or mood changes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include drowsiness, confusion, fast heartbeat, lightheadedness, and dilated pupils.
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
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