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D.H.E. 45

(other types of D.H.E. 45)

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Information on D.H.E. 45

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Learn more about usage, cautions, and possible side effects .

1ml Ampule
Chemical Name: DIHYDROERGOTAMINE (dye-hye-droe-er-GOT-a-meen)

Common uses
This medicine is an ergot derivative used to prevent and treat migraine headaches.

Before using
WARNING: Infrequently, a very serious, life-threatening decrease in the amount of blood supply to the hands and feet (peripheral ischemia) and rarely to the brain can occur when this medication is taken with drugs that affect liver metabolism (e.g., potent CYP 3A4 enzyme inhibitors). Do not take this medication with macrolide antibiotics (e.g., erythromycin, clarithromycin, troleandomycin), HIV protease inhibitors (e.g. ritonavir, nelfinavir, indinavir, amprenavir, saquinavir), azole antifungals (e.g., ketoconazole, itraconazole). Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking efavirenz. Also see WARNING statement above. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking sumatriptan, nefazodone, fluconazole, fluoxetine, fluvoxamine, zileuton, clortrimazole & other mild CYP 3A4 enzyme inhibitors. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of high blood pressure or heart or kidney conditions. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.

Directions
Follow the directions for using this medicine provided by your doctor. This medicine is sometimes used at home as an injection. Before using this medicine, a healthcare professional will provide detailed instructions for its appropriate use. Ask any questions that you may have about this medicine or giving injections. DO NOT use daily on a regular basis. AVOID EATING GRAPEFRUIT OR DRINKING GRAPEFRUIT JUICE while taking this medicine. STORE THIS MEDICINE at room temperature in a tightly-closed container, away from heat and light. Do not use if solution is discolored.

Cautions
DO NOT USE MORE THAN 6 DOSES PER WEEK, unless otherwise directed by your doctor. If your symptoms do not improve or if they become worse, check with your doctor. FOR WOMEN: DO NOT USE THIS MEDICINE if you are pregnant. IF YOU SUSPECT THAT YOU COULD BE PREGNANT contact your doctor immediately. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine.

Possible side effects
SIDE EFFECTS, that may go away during treatment, include nausea or vomiting. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience numbness or tingling of your fingers or toes; muscle pain or weakness in the arms or legs; chest pain or a change in heart rate; or swelling or itching at the injection site. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Drug interactions
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions

If you take too much
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include numbness, tingling, and bluish discoloration of fingers and toes; slow breathing; confusion; nausea; vomiting; stomach pain; and seizures.

Additional information
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full.

Selected data included with permission and copyrighted by Medi-Span, 2009. This copyrighted material has been downloaded from a Licensed data provider and is not for distribution in professional healthcare settings.