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What are the side effects of Glucophage?

Glucophage (generic name metformin) is a medicine used with diet and exercise to help reduce blood sugar levels in people with type 2 (adult onset) diabetes. It may also be used to treat polycystic ovary syndrome, a hormonal condition in women.

The most common side effects of Glucophage are nausea and vomiting, diarrhea, gas, headache, dizziness, metallic taste and fatigue. These side effects usually diminish after people have taken Glucophage for a few weeks.

The most serious side effect associated with Glucophage is a condition called lactic acidosis--a rare but dangerous condition that is mainly a risk for patients who also have kidney problems. You should not use Glucophage if you have kidney or liver problems. Signs of lactic acidosis include general body discomfort, muscle pain, difficulty breathing, stomach pain, chills, lightheadedness, or slow heartbeat. Contact your doctor if you have any of these symptoms.

Surgery may also increase the side effects of Glucophage. Most patients should stop taking the medicine prior to surgery, and not restart it until they're eating and drinking normally again. Ask your doctor for specific instructions about Glucophage if you are planning to have surgery.

Sources:
Drug Facts and Comparisons. Facts and & Comparisons, 2006.
Glucophage Product Information, Bristol-Myers Squibb Company, June 2006.
Micromedex® Healthcare Series. Thomson Micromedex, 2006.

This answer prepared 8/27/2000.
This information updated 1/25/2007.