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Are there any interactions with Sarafem?

Sarafem (generic name >fluoxetine) is a new drug that treats the symptoms of severe premenstrual syndrome (PMS), also called premenstrual dysphoric disorder (PMDD). Sarafem contains the same active ingredient as the antidepressant drug Prozac--and, for this reason, patients should not take both drugs together.

Sarafem may interact with several other drugs. Do not take Sarafem in combination with sibutramine (brand name Meridia) or monoamine oxidase inhibitors (MAOIs) such as tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl). These may cause high blood pressure, fever, or seizures. Some people experience mood swings, restlessness, sweating, chills, and tremor.

You may increase side effects if you take Sarafem in combination with terfenadine (Seldane), astemizole (Hismanal), clarithromycin (Biaxin), tramadol (Ultram), or phenytoin (Dilantin). Discuss your medicines with your doctor if you are taking warfarin (Coumadin), digoxin (Lanoxin), tryptophan, sleeping pills, or tranquilizers. For some people, Sarafem raises the level of these medicines in the blood, increasing side effects.

Sources:
Sarafem product information, Eli Lilly and Company, 2001.
Micromedex Healthcare Series. Micromedex, Inc., 2001.

This answer prepared 8/13/01.