Learn more about usage, cautions, and possible side effects .
Chemical Name: ISONIAZID (eye-soe-NYE-a-zid), RIFAMPIN (rif-AM-pin), and PYRAZINAMIDE (peer-a-ZIN-a-mide)
This medicine is an antibacterial combination used to treat tuberculosis (TB).
This medicine may cause severe and sometimes fatal liver problems (eg, hepatitis). The risk of liver problems is greater in patients older than 35 years old. It may also be increased by daily use of alcohol, long-term liver problems or unsanitary injectable drug use. Women, especially those who are black, Hispanic, or have just had a baby, may also be at increased risk. Hepatitis can develop at any time during treatment but usually occurs during the first 3 months. Your doctor will monitor your liver function and discuss your progress every month. Contact your doctor right away if you develop unusual fatigue, weakness or fever that lasts longer than 3 days, general feeling of discomfort, loss of appetite, nausea, vomiting, numbness or tingling of the hands or feet, dark urine, yellowing of the skin or eyes, or stomach pain or tenderness. Patients with active liver problems should not use this medicine. Some medicines or medical conditions may interact with this medicine. DO NOT TAKE THIS MEDICINE if you are also taking ranolazine, temsirolimus, a tyrosine kinase receptor inhibitor (such as lapatinib), or voriconazole. Many other prescription and nonprescription medicines (such as those used for alcoholism, allergic reactions, anxiety, arthritis, asthma, birth control, blood pressure, blood thinning, cancer, cholesterol, depression, diabetes, Hansen disease, heart problems, HIV, hormone replacement, immune system suppression, infections, irregular heartbeat, mental or mood problems, nausea and vomiting, pain, Parkinson disease, seizures, sleep) may interact with this medicine, increasing the risk of side effects or decreasing effectiveness. Multivitamin products and herbal or dietary supplements (such as herbal teas, coenzyme Q10, garlic, ginseng, gingko, St. John's wort) may also interact with this medicine, increasing the risk of side effects or decreasing effectiveness. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT START OR STOP any medicine without doctor or pharmacist approval. TELL YOUR DOCTOR if you wear contact lenses, are more than 35 years old, have recently given birth, or have previously taken this medicine. Inform your doctor of any other medical conditions including the blood disease porphyria, diabetes, kidney problems, nerve problems (such as neuropathy) or a risk for nerve problems, HIV, severe diarrhea due to antibiotic use (pseudomembranous colitis), allergies, pregnancy, or breast-feeding. Inform your doctor if you have a history of liver problems, gout, alcohol or other substance abuse, unsanitary injectable drug habits, or if you drink alcohol daily. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have active gout, severe liver damage, active liver disease, liver damage or severe side effects (such as drug fever, chills, or arthritis) from previous use of isoniazid, or if you have a history of hepatitis caused by any medicine. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
Follow the directions for using this medicine provided by your doctor. TAKE THIS MEDICINE ON AN EMPTY STOMACH at least 1 hour before or 2 hours after eating. TAKE THIS MEDICINE WITH A FULL GLASS OF water (8 oz/240 mL). IF YOU ALSO TAKE AN ANTACID, take this medicine at least 1 hour before you take the antacid. If you also take aminosalicylic acid granules, do not take it within 8 to 12 hours of this medicine. Check with your doctor if you have questions. STORE THIS MEDICINE at room temperature between 59 and 86 degrees F (15 and 30 degrees C), in a tightly-closed container, away from heat and light. TO CLEAR UP YOUR INFECTION COMPLETELY, continue taking this medicine for the full course of treatment even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or if you are allergic to any ingredient in this product. DO NOT STOP TAKING THIS MEDICINE without first checking with your doctor. Rarely, kidney problems have occurred when patients started taking this medicine again after stopping therapy. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure laboratory personnel and your doctors know you use this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. This medicine may cause drowsiness or dizziness. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. THIS MEDICINE MAY CAUSE nerve problems. You may be at increased risk of developing nerve problems if you have a history of diabetes or alcohol abuse. Notify your doctor if you notice any unusual tingling in your hands or feet. CHECK WITH YOUR DOCTOR before drinking alcohol while you are taking this medicine. DO NOT EAT FOODS HIGH IN TYRAMINE (such as aged cheeses, red wines, beer, certain meats and sausages, liver, sour cream, soy sauce, raisins, bananas, avocados) while you take this medicine as this may cause severe high blood pressure. Seek medical attention at once if you develop severe headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting, sweating, enlarged pupils, or sensitivity to light. DO NOT EAT FOODS HIGH IN HISTAMINE (such as skipjack, tuna, tropical fish) while you take this medicine as this may cause low blood pressure, irregular heartbeat, headache, sweating, or flushing. Contact your doctor at once if any of these symptoms occur. Ask your health care provider for a complete list of foods you should avoid while you are taking this medicine. THIS MEDICINE MAY CAUSE your urine, stools, saliva, sweat, tears, or skin to turn orange or red. This is harmless. THIS MEDICINE MAY PERMANENTLY STAIN soft contact lenses. MILD DIARRHEA IS COMMON WITH ANTIBIOTIC USE. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. This includes acetaminophen and medicines that contain acetaminophen. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN BLACK and HISPANIC WOMEN or in patients over than 35 years old because they may have a greater risk of severe liver problems from this medicine. FOR WOMEN TAKING BIRTH CONTROL PILLS, this medicine may decrease the effectiveness of your birth control pill. To prevent pregnancy, use an additional form of birth control. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby. IF YOU HAVE DIABETES, may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
SIDE EFFECTS that may occur while taking this medicine include diarrhea, dizziness, drowsiness, gas, headache, heartburn, mild stomach upset or cramps, nausea, or trouble sleeping. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience changes in vision, memory problems, menstrual changes, mental or mood changes, or symptoms of low vitamin B6 levels (such as scaly rash, cracks in the corners of the mouth, mouth redness or soreness, confusion, irritability). CONTACT YOUR DOCTOR IMMEDIATELY if you experience bloody stools; chills or fever; dark urine; change in the amount of urine produced; coughing up blood; general feeling of discomfort; increased thirst or urination; irregular heartbeat; joint pain or swelling; loss of appetite; seizures; ringing in the ears; severe diarrhea or nausea; severe stomach pain, cramps, or tenderness; shortness of breath; severe pain or tenderness in the big toe; swelling of the hands or legs; tingling or numbness in the hands or feet; unusual bruising or bleeding; unusual tiredness or weakness; vomiting; or yellowing of the skin or eyes. AN ALLERGIC REACTION TO THIS MEDICINE is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, hives, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms may include blurred vision, hallucinations, loss of consciousness, seizures, severe dizziness or nausea, sluggishness, slurred speech, stomach pain or tenderness, symptoms of high blood sugar (such as increased thirst or urination, rapid breathing, confusion, unusual drowsiness), very slow breathing, vomiting, and yellowing of the skin or eyes.
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
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