Combivir

Information on Combivir

Tablets
Chemical Name: LAMIVUDINE (la-MI-vyoo-deen) and ZIDOVUDINE (zye-DOE-vyoo-deen)

Common uses
This medicine is an antiviral combination used with other medicines to treat human immunodeficiency virus (HIV) infection.

Before using
WARNING: THIS MEDICINE HAS CAUSED HAS CAUSED SEVERE, EVEN FATAL, LIVER PROBLEMS AND BLOOD DISORDERS, including a buildup of lactic acid in the blood (lactic acidosis), neutropenia, and anemia, especially in patients with advanced HIV infection. IF YOU ALSO HAVE HEPATITIS B INFECTION, WORSENING OF YOUR CONDITION COULD OCCUR if you stop taking this medicine without your doctor knowing. DO NOT STOP TAKING THIS MEDICINE without your doctor's approval. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking other forms of lamivudine or zidovudine, zalcitabine, stavudine, ribavirin, or doxorubicin. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking ganciclovir, interferon-alpha, probenecid, or methadone. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including pancreatitis, kidney problems, hepatitis B infection or other liver problems, abnormal blood counts, muscle problems, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of abnormal liver function tests, severe liver problems, severe kidney problems, or lactic acidosis. Use of this medicine in children under age 12 is not recommended. Discuss with your doctor the risks and benefits of giving this medicine to your child. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

Directions
Follow the directions for taking this medicine provided by your doctor. This medicine may be taken on an empty stomach or with food. STORE THIS MEDICINE at room temperature or in the refrigerator in a tightly-closed container, away from heat and light. CONTINUE TO TAKE THIS MEDICINE even if you feel well. It is important not to miss doses of this medicine. Taking this medicine at the same times each day will help you to remember. IF YOU MISS A DOSE OF THIS MEDICINE, use it as soon as possible. If it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT TAKE 2 doses at once.

Cautions
DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. DO NOT EXCEED THE RECOMMENDED DOSE of this medicine without checking with your doctor. Exceeding the recommended dose of this medicine may not provide additional benefits and may increase the risks of side effects. THIS MEDICINE IS NOT A CURE FOR HIV INFECTION and will not prevent you from spreading HIV infection to others through sexual contact. THIS MEDICINE MAY NOT PREVENT OTHER INFECTIONS. If your health changes, check with your doctor. DO NOT STOP TAKING THIS MEDICINE without first checking with your doctor. Some conditions may become worse when the medicine is suddenly stopped. Laboratory and/or medical tests, including blood counts, and liver and kidney function tests may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. The use of lamivudine, abacavir, and tenofovir in combination may not be effective in treating HIV infection. If you are currently taking all three of these medicines, contact your doctor as soon as possible to carefully review your medicines. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN CHILDREN with a history of pancreatitis, or who have taken other medicines for HIV infection. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking this medicine.

Possible side effects
SIDE EFFECTS that may occur while taking this medicine include headache, dizziness, tiredness, decreased appetite, nausea, vomiting, diarrhea, indigestion, difficulty sleeping, sinus drainage, and coughing, or changes in body fat (such as increased fat in the upper back and stomach areas, or decreased fat in the arms and legs). If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience swelling or soreness of the mouth or tongue; numbness or tingling in your arms or legs; severe muscle or joint pain; unusual weakness or exhaustion; unusual bleeding or bruising; or depression/mental or mood changes. CONTACT YOUR DOCTOR IMMEDIATELY if you experience irregular heartbeat; persistent sore throat, chills, or fever; severe stomach pain, darkening of your urine, or seizures. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Drug interactions
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions

If you take too much
IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, drowsiness, tiredness, confusion, and seizures.

Additional information
If you have any questions concerning how to prevent spreading HIV infection to other people, ask your doctor, nurse, or pharmacist. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF YOU WILL BE USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, be sure to obtain necessary refills before your supply runs out.

Selected data included with permission and copyrighted by Medi-Span, 2008. This copyrighted material has been downloaded from a Licensed data provider and is not for distribution in professional healthcare settings.